Neil Mackenzie
Neil practising at low altitude.
Neil Mackenzie is a Molecular biologist at the Roslin Institute. He is currently investigating mechanisms of vascular calcification and testing potential therapeutics for calcific aortic stenosis. He is a keen climber and ski-mountaineer having climbed and ski-toured widely in Scotland, the European Alps, the Canadian Rockies and Alaska.
Recent publications:
1. Altered bone development and an increase in FGF-23 expression in Enpp1(-/-) mice.
Mackenzie NC, Zhu D, Milne EM, van 't Hof R, Martin A, Quarles DL, Millan JL, Farquharson C, MacRae VE.PLoS One. 2012;7(2):e32177. PMID: 22359666
2. The appearance and modulation of osteocyte marker expression during calcification of vascular smooth muscle cells.
Zhu D, Mackenzie NC, Millan JL, Farquharson C, MacRae VE.PLoS One. 2011;6(5):e19595. PMID: 21611184
3. MOVAS-1 cell line: a new in vitro model of vascular calcification.
Mackenzie NC, Zhu D, Longley L, Patterson CS, Kommareddy S, MacRae VE.Int J Mol Med. 2011 May;27(5):663-8. doi: 10.3892/ijmm.2011.631. PMID: 21369692
4. Evaluation of RNA-knockdown strategies for modulation of cytochrome P450 reductase activity in mouse hepatocytes.
Mackenzie NC, Lillico SG, Brown K, Wolf CR, Whitelaw CB.J RNAi Gene Silencing. 2010 Nov 26;6(2):416-21. PMID: 21350684
5. The role of cellular senescence during vascular calcification: a key paradigm in aging research.
Mackenzie NC, MacRae VE.Curr Aging Sci. 2011 Jul;4(2):128-36. PMID: 21235497
