
PUBLICATIONS
APEX research has led to the publication of multiple scientific papers. Continued research into the effects of high altitude on human physiology has the potential to benefit not only future travellers to high altitude, but also patients who are affected by a shortage of oxygen because of lung disease or critical illness.
1. Sanchez-Garcia MA, Sadiku P, Ortmann BM, Wit N, Negishi Y, Coelho P, Zhang A, Pednekar C, Howden AJM, Griffith DM, Seear R, Kindrick JD, Mengede J, Cooper G, Morrison T, Watts ER, Shimeld BT, Reyes L, Mirchandani AS, Arienti S, Xu X, Thomson A, Brenes AJ, Turton HA, Dowey R, Hull RC, Davidson-Smith H, McLaren A, Deans A, Choudhury G, Doverman K, Hope D, Vick O, Woodhead A, Petrie I, Green S, Rzechorzek NM, Turtle L, Openshaw PJM, Semple MG; PHOSP-COVID Study Collaborative Group; Sproul D, Baillie JK, Thompson AAR, Mole DR, von Kriegsheim A, Whyte MKB, Mhlanga MM, Nathan JA, Walmsley SR. Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity. Nat Immunol. 2025;26(11):1903-1915. https://doi.org/10.1038/s41590-025-02301-9
2. Turton HA, Pickworth J, Paterson GG, Lawrie A, Baillie JK, Thompson AAR. Soluble P-selectin and von Willebrand factor rise in healthy volunteers following non-exertional ascent to high altitude. Front Physiol. 2022;13:825819. https://doi.org/10.3389/fphys.2022.825819
3. Sadiku P, Willson JA, Ryan EM, Sammut D, Coelho P, Watts ER, Grecian R, Young JM, Bewley M, Arienti S, Mirchandani AS, Sanchez-Garcia MA, Morrison T, Zhang A, Reyes L, Griessler T, Jheeta P, Paterson GG, Graham CJ, Thomson JP, Baillie JK, Thompson AAR, Walmsley SR. Neutrophils fuel effective immune responses through gluconeogenesis and glycogenesis. Cell Metab. 2021;33(3):411-423.e4. https://doi.org/10.1016/j.cmet.2020.11.016
4. Paterson GG, Young JM, Willson JA, Graham CJ, Dru RC, Lee EW, Torpey GS, Walmsley SR, Chan MV, Warner TD, Baillie JK, Thompson AAR. Hypoxia modulates platelet purinergic signalling pathways. Thromb Haemost. 2020;120(2):253-261. https://doi.org/10.1055/s-0039-3400305
5. Young JM, Williams DR, Thompson AAR. Thin air, thick vessels: historical and current perspectives on hypoxic pulmonary hypertension. Front Med (Lausanne). 2019;6:93. https://doi.org/10.3389/fmed.2019.00093. PMC6504829
6. Thompson AAR. Altitude research on Mount Chacaltaya, Bolivia. 2018. In: Chinthapalli K. Physicians and global health. London: Royal College of Physicians; 2018.
7. Rocke AS, Paterson GG, Barber MT, Jackson AIR, Main SE, Stannett C, Schnopp MF, MacInnis M, Baillie JK, Horn EH, Thompson AAR. Thromboelastometry and platelet function during acclimatization to high altitude. Thromb Haemost. 2018;118(1):63-71. PMC626011
8. Roach RC, Hackett PH, Oelz O, Bärtsch P, Luks AM, MacInnis MJ, Baillie JK. The 2018 Lake Louise acute mountain sickness score. High Alt Med Biol. 2018;19(1):4-6. PMC6191821
9. Hall DP, MacCormick IJC, Phythian-Adams AT, Rzechorzek NM, Hope-Jones D, Cosens S, Jackson S, Bates MGD, Collier DJ, Hume DA, Baillie JK. Network analysis reveals distinct clinical syndromes underlying acute mountain sickness. PLoS One. 2014;9(1):e81229. PMC3898916
10. Pagani L, Ayub Q, MacArthur DG, Xue Y, Baillie JK, Chen Y, Kozarewa I, Turner DJ, Tofanelli S, Bulayeva K, Tyler-Smith C. High altitude adaptation in Daghestani populations from the Caucasus. Hum Genet. 2012;131(3):423-433. PMC3312735
11. MacCormick IJC, Somner J, Morris DS, MacGillivray TJ, Bourne RRA, Huang SS, MacCormick A, Aspinall PA, Baillie JK, Thompson AAR, Dhillon B. Retinal vessel tortuosity in response to hypobaric hypoxia. High Alt Med Biol. 2012;13(4):263-268. https://doi.org/10.1089/ham.2011.1097
12. Hall DP, Duncan K, Baillie JK. High altitude pulmonary oedema. J R Army Med Corps. 2011;157(1):68-72
13. Bates MGD, Thompson AAR, Baillie JK, Sutherland AI, Irving JB, Hirani N, Webb DJ. Sildenafil citrate for the prevention of high altitude hypoxic pulmonary hypertension: double blind, randomized, placebo-controlled trial. High Alt Med Biol. 2011;12(3):207-214. https://doi.org/10.1089/ham.2011.0007
14. Jackson SJ, Varley J, Sellers C, Josephs K, Codrington L, Duke G, Njelekela MA, Drummond G, Sutherland AI, Thompson AAR, Baillie JK. Incidence and predictors of acute mountain sickness among trekkers on Mount Kilimanjaro. High Alt Med Biol. 2010;11(3):217-222. https://doi.org/10.1089/ham.2010.1003
15. Thompson AAR, Baillie JK, Bates MGD, Schnopp MF, Simpson A, Partridge RW, Drummond GB, Mason NP. The citric acid cough threshold and the ventilatory response to carbon dioxide on ascent to high altitude. Respir Med. 2009;103(8):1182-1188. https://doi.org/10.1016/j.rmed.2009.02.007
16. Baillie JK, Thompson AAR, Irving JB, Bates MGD, Sutherland AI, Macnee W, Maxwell SRJ, Webb DJ. Oral antioxidant supplementation does not prevent acute mountain sickness: double blind, randomized placebo-controlled trial. QJM. 2009;102(5):341-348. https://doi.org/10.1093/qjmed/hcp026
17. Toshner MR, Thompson AAR, Irving JB, Baillie JK, Morton JJ, Peacock AJ. NT-proBNP does not rise on acute ascent to high altitude. High Alt Med Biol. 2008;9(4):307-310. https://doi.org/10.1089/ham.2008.1054
18. Mytton OT, Simpson A, Thompson AAR, Oram RA, Darowski A, Yu L, Collier DJ, Pollard AJ. Manual assessment of the initial fall in blood pressure after orthostatic challenge at high altitude. Wilderness Environ Med. 2008;19(3):225-232. https://doi.org/10.1580/07-WEME-OR-097.1
19. Somner JEA, Morris DS, Scott KM, MacCormick IJC, Aspinall P, Dhillon B. What happens to intraocular pressure at high altitude? Invest Ophthalmol Vis Sci. 2007;48(4):1622-1626. https://doi.org/10.1167/iovs.06-1238
20. Morris DS, Severn PS, Smith J, Somner JEA, Stannard KP, Cottrell DG. High altitude and retinal detachment. High Alt Med Biol. 2007;8(3):337-339. https://doi.org/10.1089/ham.2007.1026
21. Morris DS, Somner JEA, Scott KM, MacCormick IJC, Aspinall P, Dhillon B. Corneal thickness at high altitude. Cornea. 2007;26(3):308-311. https://doi.org/10.1097/ICO.0b013e31802e63c8
22. Dorward DA, Thompson AAR, Baillie JK, MacDougall M, Hirani N. Change in plasma vascular endothelial growth factor during onset and recovery from acute mountain sickness. Respir Med. 2007;101(3):587-594. https://doi.org/10.1016/j.rmed.2006.06.014
23. Bates MGD, Thompson AAR, Baillie JK. Phosphodiesterase type 5 inhibitors in the treatment and prevention of high altitude pulmonary edema. Curr Opin Investig Drugs. 2007;8(3):226-231
24. Baillie JK, Bates MGD, Thompson AAR, Waring WS, Partridge RW, Schnopp MF, Simpson A, Gulliver-Sloan F, Maxwell SRJ, Webb DJ. Endogenous urate production augments plasma antioxidant capacity in healthy lowland subjects exposed to high altitude. Chest. 2007;131(5):1473-1478. https://doi.org/10.1378/chest.06-2235
25. Morris DS, Somner J, Donald MJ, MacCormick IJC, Bourne RRA, Huang SS, Aspinall P, Dhillon B. The eye at altitude. Adv Exp Med Biol. 2006;588:249-270. https://doi.org/10.1007/978-0-387-34817-9_21
26. Thompson AAR, Baillie JK, Toshner M, Maxwell SRJ, Webb DJ, Irving JB. Pericardial effusions in healthy lowlanders after acute ascent to high altitude. Heart. 2006;92(4):539-540. PMC1860857
27. Smith EMD, Baillie JK, Thompson AAR, Irving JB, Porteous D, Webb DJ. Endothelial nitric oxide synthase polymorphisms do not influence pulmonary artery systolic pressure at altitude. High Alt Med Biol. 2006;7(3):221-227. https://doi.org/10.1089/ham.2006.7.221
28. Baillie JK, Thompson AR, Bates MG, Schnopp M, Simpson A, Partridge R. The Chacaltaya High Altitude Laboratory. J R Coll Physicians Edinb. 2004;34(2):130-133
